About Me
Education
Ph.D. in Neuroscience and Neuropharmacology
University of Brighton
Masters of Science in Health Communications
Boston University
Bachelor of Arts in Biochemistry and Molecular Biology
Hendrix College
Affiliations
Publications
Keine D. Depression-inducing drugs and the frequency of depression in Alzheimer’s disease and APOE ε4 carriers. F1000Research 2019, 8:1782
Keine D, Zelek M, Walker JQ, Sabbagh MN. Polypharmacy in an Elderly Population: Enhancing Medication Management Through the Use of Clinical Decision Support Software Platforms. Neurol Ther. 2019 Jun;8(1):79-94.
Keine D, Walker JQ, Kennedy BK, Sabbagh MN. Development, Application, and Results from a Precision-medicine Platform that Personalizes Multi-modal Treatment Plans for Mild Alzheimer’s Disease and At-risk Individuals. Curr Aging Sci. 2018;11(3):173-181.
Zelek M, Keine D, Walker JQ, Sabbagh M. Enhancing Medication Management through the Use of Clinical Decision Support Software Platforms. Alzheimer’s and Dementia, 2018; July.
Keine D, Walker JQ, Sabbagh M. Development, Application, and Results from a Precision-Medicine Platform That Personalizes Multi-Modal Care Plans for Mild Alzheimer’s Disease and Those at Risk. Alzheimer’s and Dementia, 2018; July.
Keine D, Walker JQ, Sabbagh M. Observations on the Frequency of Depression and Medications in an Apoe ε4 Vs Non-Apoe ε4 Population. Alzheimer’s and Dementia, 2018; July.
Walker JQ, Keine D, Sabbagh M. Development, Application, and Results from a Clinical Informatics Platform That Enables a Multi-Model Treatment Protocol for Alzheimer’s Disease. Alzheimer’s and Dementia, 2017.
Walker JQ, Keine D, Caesar E, Hristov H, Hackett K, Isaacson R. Comparing Clinically Based Versus Algorithm-Generated Interventions in the Context of Alzheimer’s Disease Prevention. Alzheimer’s and Dementia, 2017.
Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Burchett JM, Schuler DR, Cirrito JR, Diwan A, Lee JM. Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis. J Neurosci. 2014 Jul 16;34(29):9607-20.
Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer’s disease. J Neurosci. 2014 Mar 12;34(11):3826-40.
Fowler SW, Chiang AC, Savjani RR, Larson ME, Sherman MA, Schuler DR, Cirrito JR, Lesné SE, Jankowsky JL. Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer’s disease. J Neurosci. 2014 Jun 4;34(23):7871-85.
Kanekiyo T, Cirrito JR, Liu CC, Shinohara M, Li J, Schuler DR, Shinohara M, Holtzman DM, Bu G. Neuronal clearance of amyloid-β by endocytic receptor LRP1. J Neurosci. 2013 Dec 4;33(49):19276-83. doi: 10.1523/JNEUROSCI.3487-13.2013.
DeVos SL, Goncharoff DK, Chen G, Kebodeaux CS, Yamada K, Stewart FR, Schuler DR, Maloney SE, Wozniak DF, Rigo F, Bennett CF, Cirrito JR, Holtzman DM, Miller TM. Antisense reduction of tau in adult mice protects against seizures. J Neurosci. 2013 Jul 31;33(31):12887-97.
Ulrich JD, Burchett JM, Restivo JL, Schuler DR, Verghese PB, Mahan TE, Landreth GE, Castellano JM, Jiang H, Cirrito JR, Holtzman DM. In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Mol Neurodegener. 2013 Apr 19;8:13.
Schuler D, and Kozlowicz A. Complete chromosome sequence of MACACA MULATTA BAC clone CH250- 250P5. GenBank, 2009.